The Anti-Hsc70/Hsp73 Monoclonal Antibody from MyBioSource.com is a Mouse Monoclonal antibody. This antibody recognizes Human, Mouse, and Rat antigen. The Anti-Hsc70/Hsp73 Monoclonal Antibody has been validated for the following applications: ELISA, Immunohistochemistry, Immunoprecipitation, and Western Blot.
Description
Hsp70 genes, members of a multigene family, encode heat-inducible 70kDa heatshock proteins that function as molecular chaperones. They have been identified in most organelles of eukaryotic cells as well as in bacteria. The N-terminus of Hsp70 binds ATP with high affinity and the Cterminus binds proteins and polypeptides. When cells are subjected to metabolic stress, Hsp70 is expressed. Hsp70 shares >90% sequence homology with Hsc70. Constitutively expressed Hsc70 forms a stable complex with the highly inducible Hsp70 in cells following heat shock. This interaction is regulated by ATP. Research on Hsc70 suggests that it plays a role in facilitating the recovery of centrosomal structure and function after heat shock